The article discusses the complex mechanisms behind cancer development and resistance, focusing particularly on the genetic alterations that initiate various cancers. It highlights that certain tumor suppressor genes, like Rb, play crucial roles in preventing cancers from forming, even in the presence of oncogenic mutations. Notably, normal development, rather than cell death or immune responses, is presented as the primary factor allowing many cells to evade tumorigenesis. The author emphasizes the need for further exploration into these mechanisms to inform better cancer prevention and treatment strategies.
Cancers arise from distinct genetic changes indicating context-specific responses, and while many normal cells harbor oncogenic mutations, an escape mechanism prevents tumor development.
Cell death is usually seen as a resistance factor to cancer, but actually, normal development is the mechanism that allows Rc-negative cells to avoid tumors.
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