"In medicine, dose has always mattered. In psychedelic therapeutics, however, attention often centers on the choice of compound and the importance of set and setting, while dose receives comparatively less focus. Outcomes are shaped not only by the molecule itself but by the dose range in which it is administered. Different doses can produce distinct subjective states, engage different psychological and neurobiological mechanisms, and require very different therapeutic interventions."
"This dose‑sensitive perspective is shaping how myself and others in the field think about developing safe, effective, and affordable psychedelic treatments. By understanding dose categories more precisely, we can match the right level of intensity to the right therapeutic need. Below, I outline four broad dose categories, informed by existing literature and ongoing conversations with researchers across the field."
Dose selection in psychedelic treatment significantly influences therapeutic effects, safety, and care requirements. Different dose ranges produce distinct subjective experiences and engage different psychological and neurobiological mechanisms. Microdoses often produce no noticeable psychoactive effects and have mixed or placebo-like trial results. Mid-range doses may provide therapeutic benefits with lower intensity, resource needs, and cost than full high-dose sessions. Clear categorization of dose ranges enables the design of appropriate therapeutic interventions and allocation of clinical resources. Matching dose categories to specific clinical needs can improve safety, effectiveness, and accessibility. Expanded dosing research can broaden treatment options and inform care models.
Read at Psychology Today
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