Microglia, as tissue resident macrophages in the central nervous system, fulfill multiple crucial roles during both homeostasis and disruptions. They interact with neurons via synaptic engulfment and are responsible for the rapid removal of apoptotic cells and dysfunctional synapses. This research introduces an innovative interaction between microglia and neurons, where microglia provide the lysosomal enzyme -hexosaminidase (Hex) to neurons. This enzyme is pivotal for breaking down the ganglioside GM2, which is vital for neuronal maintenance and functionality.
The study reveals that microglia deliver the lysosomal enzyme -hexosaminidase (Hex) to neurons. This process aids in the degradation of ganglioside GM2 critical to neuronal function.
Using lipidomics, spatial lipid imaging, and single-cell transcriptome analysis, researchers uncovered a novel interaction between microglia and neurons, highlighting microglial functions beyond their established roles.
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