"Ozempic, Mounjaro, and Zepbound can drive impressive weight loss, but stopping them is often followed by rapid weight regain. Researchers found that people regain weight faster after quitting these drugs than after diet and exercise alone. Improvements in heart health and diabetes risk also tend to reverse within a few years. The results suggest long-term success may require more than medication alone."
"On average, individuals regained about 0.4 kilograms per month after stopping medication. Based on these trends, body weight and key risk markers for diabetes and heart disease were projected to return to pre-treatment levels in under two years. The study also found that weight regain after stopping medication happened much faster than after weight loss achieved through diet and physical activity. In fact, the pace of regain was nearly four times higher, regardless of how much weight a person initially lost."
People who stop taking GLP-1 prescription weight-loss drugs often regain weight quickly and lose many of the heart and metabolic health gains they made. Average weight regain is about 0.4 kilograms per month after stopping medication. Based on observed trends, body weight and key risk markers for diabetes and heart disease can return to pre-treatment levels in under two years. Weight regain after drug cessation occurs nearly four times faster than after weight loss achieved through diet and exercise, regardless of initial weight loss magnitude. Improvements in cholesterol and blood pressure tend to fade within a few years. Sustainable long-term control likely requires more than medication alone.
Read at ScienceDaily
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