A comprehensive review by HHS on transgender treatments for minors reveals significant uncertainty regarding their benefits, urging a pivot toward behavioral therapy for gender dysphoria. The 409-page report indicates many treatments gained traction without thorough safety studies, emphasizing the low quality of evidence linking these interventions to positive mental health outcomes. Specifically, treatments like puberty blockers and hormone therapy were found to lack substantial claims of efficacy. The review, commissioned following President Trump's executive order, highlights the necessity of stringent evaluation in pediatric transition protocols before broader application.
The umbrella review found that the overall quality of evidence concerning the effects of any intervention on psychological outcomes, quality of life, regret, or long-term health, is very low.
This indicates that the beneficial effects reported in the literature are likely to differ substantially from the true effects of the interventions.
While the report stressed it is not a clinical practice guideline, the paper examined 17 systematic reviews of transgender treatments in minors.
In some instances, this was because studies did not properly measure track patient outcomes or studied individuals whose mental health was already at a high-functioning at baseline.
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