"After a one-yard run with 12:26 remaining in the third quarter, Cardinals running back James Conner was down due to injury. The cart had to come out for Conner, and that is rarely a good sign. Sources confirmed after Arizona's Week 3 loss that it was a season-ending injury for James Conner. Over his career, Conner has missed time due to injury. However, this is the most time he'll miss in a single season."
"The 2-0 Arizona Cardinals were on the road Sunday to face the San Francisco 49ers. It was a low-scoring game in Week 3 between these NFC West rivals. In the end, the 49ers won 16-15 on a walk-off field goal. During that Week 3 loss to the 49ers, Arizona Cardinals running back James Conner suffered a serious ankle injury. The 30-year-old had to be carted off the field."
James Conner suffered a serious ankle injury during Arizona's Week 3 loss to the San Francisco 49ers and was carted off the field. NFL insiders confirmed the injury is season-ending, and Conner will miss the final 14 games of the 2025 regular season and undergo ankle surgery. The 30-year-old played three games in 2025 after staying healthy in 2024, when he started 16 games and rushed for over 1,000 yards. Conner had recorded back-to-back 1,000-yard seasons with at least seven rushing touchdowns each. The Cardinals will turn to backup running backs, including Trey Benson, to fill the void.
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