""For 30 years, we've taught students that the mouse olfactory epithelium is divided into a handful of broad zones, within which receptor choice is essentially random.""
""This is a landmark paper that overturns one of the foundational textbook models of olfactory organization.""
""Each receptor adopts a particular position in the nose. Since there are a thousand positions in the nose, each receptor is expressed basically in a stripe that overlaps with other receptor stripes, in a thousand overlapping stripes.""
""The authors found that a molecule called retinoic acid had a key role in this process.""
Research reveals that approximately 1,100 olfactory receptors in the mouse nose are organized in distinct spatial locations within the nasal cavity's epithelial tissue. This organization aligns with smell maps in the olfactory bulb of the brain. The study utilized single-cell sequencing and spatial transcriptomics to identify and map receptor expression. Findings indicate that receptors are arranged in horizontal stripes, with each receptor occupying a specific position, influenced by developmental genes and retinoic acid gradients.
Read at Nature
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