#cell-signaling

#cell-signaling

In a summary of the study, which was partially federally funded, the authors explain that usual drug discovery approaches tackle one protein at a time, and work in cases such as kinase inhibitors -- drugs that prevent cancer cells from expanding by blocking certain proteins -- but can fall short when the disease involves interactions between multiple signaling pathways and genes.

Investigators led by Navdeep Chandel, PhD, have demonstrated that mitochondrial metabolism is crucial for T-cell proliferation and the prevention of T-cell exhaustion in cancer and chronic infection.