Ezri Konsa opened his England account in the second half, as did fellow defender Marc Guéhi after turning home the free-kick that followed Nikola Milenkovic's sending-off for a foul on Kane. Substitute Marcus Rashford added a fifth from the spot at the silenced Rajko Mitic Stadium, where a laser pen and whistle were used in a bid to distract the visitors before tempers flared in the stands and fans called for boss Dragan Stojkovic to leave.
It has been a South African summer at Lord's. After the World Test Championship triumph in June came a second to savour at the home of cricket: a tight five-run win under lights that sealed their first one-day international series victory on English soil for 27 years. For England it was another reminder of how far they have fallen since lifting the World Cup on this ground six years ago, this their fifth ODI series defeat from their last six.
Ruben Loftus-Cheek has been added to Thomas Tuchel's England squad for their upcoming World Cup qualifiers against Andorra and Serbia. Loftus-Cheek, who has made 10 appearances for England since his debut eight years ago, returns to the Three Lions set-up for the first time since November 2018. The AC Milan midfielder comes into the now 25-man party to replace Adam Wharton, who sustained a groin injury in Crystal Palace's 3-0 win against Aston Villa on Sunday.
The England-India epic that ended up like two weary prizefighters trading blows will live long in the memory, a 2-2 classic deserving immense credit for players on both sides.
Spain has had a remarkable run, securing consecutive international titles and maintaining a fearsome reputation, with only one competitive defeat in over a year.