#fatty-acid-synthase

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fromNature
5 months ago

Snapshots of acyl carrier protein shuttling in human fatty acid synthase - Nature

De novo lipogenesis is crucial for mammalian development and metabolic health, particularly during disease states.
Targeting the FASN enzyme shows therapeutic potential but requires careful consideration of its broader physiological effects.
fromwww.nature.com
5 months ago

Structural dynamics of human fatty acid synthase in the condensing cycle

In our study on human FASN, we reveal that its function does not require large rotational motion, highlighting the unsynchronized nature of catalytic reactions during fatty acid synthesis.
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