#transcription-factors

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#neocortical-excitatory-neurons #gene-regulatory-circuits #mammalian-evolution #chromatin-regulation
Roam Research
fromNature
1 day ago

Adaptive evolution of gene regulatory networks in mammalian neocortex - Nature

ZBTB18-CRE interactions govern key molecular features of neocortical excitatory neurons that evolved in mammals, controlling subtype specification and laminar positioning through gene regulatory subcircuits.
Medicine
fromNature
1 month ago

Atlas-guided discovery of transcription factors for T cell programming - Nature

Transcription factors determine CD8+ T cell states; identifying TFs that promote tissue-resident memory versus terminal exhaustion enables engineering of more effective adoptive T cell therapies.
OMG science
fromNature
1 month ago

Regulatory grammar in human promoters uncovered by MPRA-based deep learning - Nature

Massively parallel reporter assays provide cell-type-specific causal training data enabling more direct inference of DNA sequence effects on promoter activity than epigenomic maps.
fromenglish.elpais.com
8 months ago

Searching for an Alzheimer's cure in a chicken's eye

Many medical breakthroughs, whose benefits are easy for anyone to grasp, begin with scientists asking questions that are difficult for most people to understand.
Alternative medicine
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