"Researchers synthesized a series of hybrid vitamin?K analogues (linked with retinoic acid or modified side chains) that show about threefold greater potency in driving neural progenitor cells to differentiate into neurons compared to natural vitamin?K (MK?4). Mechanistic studies revealed that vitamin?K activates mGluR1?mediated signaling, triggering downstream epigenetic and transcriptional programs that steer stem cells toward a neuronal fate. Structural modeling and molecular docking showed that the lead analogue (Novel VK / compound?7) binds more strongly to mGluR1 than natural MK?4, reinforcing the receptor's central role."
"In vivo testing in mice demonstrated favorable pharmacokinetics: the analogue penetrated the blood-brain barrier, reached higher brain levels of MK?4 and was more efficiently converted intracellularly than native vitamin?K. Together, the findings point to synthetic vitamin?K derivatives as promising candidates for neuron regeneration therapies in neurodegenerative diseases - though further work is required on safety, efficacy in disease models and dosing before clinical use."
A series of hybrid vitamin K analogues linked with retinoic acid or modified side chains were synthesized and showed approximately threefold greater potency than natural vitamin K (MK?4) in driving neural progenitor cells to differentiate into neurons. Vitamin K activates mGluR1-mediated signaling, which triggers downstream epigenetic and transcriptional programs steering stem cells toward a neuronal fate. Structural modeling and docking indicated that the lead analogue (Novel VK / compound?7) binds more strongly to mGluR1 than MK?4. In vivo testing in mice demonstrated blood-brain barrier penetration, higher brain MK?4 levels, and more efficient intracellular conversion. Synthetic vitamin K derivatives are candidate agents for neuron regeneration, with further safety, efficacy, and dosing evaluation required before clinical use.
Read at Natural Health News
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