"Examining over 5,000 blood proteins from samples taken from 40 adult trans women both before and after beginning treatment, the team of biologists compared their findings with data from a long-running study of cisgender women. The study, published in Nature Medicine, found that, after taking a daily dose of estradiol and anti-androgens for six months, protein changes among the patients began to more closely align with those of cisgender women."
"Researchers discovered that feminising HRT significantly reduced protein biomarkers - molecules that act as indicators of a biological process - related to male fertility and reproduction, while driving those associated with body fat and breast development, similar to what is seen in menopausal women, who also receive HRT. Remarkably, there were also signs that feminising hormones can also strengthen the immune system and improve heart health."
"MCRI associate professor, Boris Novakovic, noted that the treatment "may go onto impact the risk of allergic and autoimmune diseases, which tend to affect more females," but also noted it can widely diminish the risk of heart disease, which he said is "more commonly seen in males." "This highlights that human biology is malleable and that even in adulthood, our bodies respond to sex hormone changes.""
Over 5,000 blood proteins were measured in 40 adult trans women before and after beginning daily estradiol and anti-androgen treatment and compared with long-term cisgender female data. After six months of feminising hormone therapy, protein profiles shifted to more closely resemble those of cisgender women. Feminising HRT significantly decreased protein biomarkers linked to male fertility and reproduction while increasing proteins associated with body fat distribution and breast development, mirroring changes seen in menopausal women receiving HRT. Additional protein changes indicated potential strengthening of immune function and reduced cardiovascular risk. Clinical monitoring and personalised HRT regimens are recommended to optimise individual health outcomes.
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