"The drugs have many overlapping actions in the brain and body, however, in general they all mimic the actions of natural gut hormones. The drugs have many biochemical benefits, such as reducing the risk of insulin resistance and promoting fat breakdown. However, the drugs are effective primarily because they reduce feelings of hunger while increasing feelings of fullness. Essentially, we simply don't feel like eating."
"Which is more effective: exercise or a drug-induced loss of appetite? In a review of 32 randomized controlled trials that involved a total of 4,774 participants with obesity, the average loss of weight of those who participated in a regular exercise routine, as compared to controls without exercise, was small; only about 2 kg. Nationwide surveys show that 43% of Americans are overweight by at least 10-15 kg."
New diet drugs mimic natural gut hormones and act on the brain to reduce hunger and increase fullness, causing major caloric reduction and substantial weight loss. These agents provide biochemical benefits such as lowering risk of insulin resistance and promoting fat breakdown. Reported reductions include up to 30% body weight in some trials. Clinical trials generally did not include exercise, indicating that appetite suppression and calorie restriction drive the weight loss. Randomized controlled trials of exercise show only modest effects—about 2 kg average weight loss. High prevalence of overweight individuals underscores potential population-level health and economic impacts.
Read at Psychology Today
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