A recent study by Mass General Brigham has demonstrated that exercise induces significant cellular changes in the brain that may help combat Alzheimer's disease. By using advanced RNA sequencing and mouse models, researchers pinpointed how specific brain cells, including microglia and a novel astrocyte type, are affected by physical activity. These findings were further validated with human brain samples, enhancing the understanding of the cellular mechanisms connecting exercise to brain health, which could inform future treatment strategies for Alzheimer's.
Exercise doesn't just help the brain-it changes it at the cellular level. Scientists found key brain cells and genes activated by exercise that may help fight Alzheimer's.
While we've long known that exercise helps protect the brain, we didn't fully understand which cells were responsible or how it worked at a molecular level.
Now, we have a detailed map of how exercise impacts each major cell type in the memory center of the brain in Alzheimer's disease.
The study focused on a part of the hippocampus -- a critical region for memory and learning that is damaged early in Alzheimer's disease.
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