Researchers at McGill University have unveiled significant insights into bipolar disorder, suggesting that mood variations stem from dual internal rhythms, specifically a sleep-wake cycle and a second clock influenced by dopamine levels. This newfound understanding may explain the typical 48-hour sleep patterns observed in those with bipolar disorder, correlating short-sleep periods with manic episodes and longer durations with depression. Disruption of dopamine-producing neurons has been linked to cessation of these behavioral variations, marking a potential breakthrough in targeting the root causes of mood fluctuations rather than merely managing symptoms.
Researchers from McGill University believe they have uncovered the 'holy grail' of bipolar disorder research by identifying the dual internal clocks that influence mood swings.
The study published in Science Advances suggests mood shifts in bipolar disorder are triggered by an interplay between the sleep-wake cycle and a dopamine-driven clock.
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