Pedro Cuatrecasas was an influential biochemist who contributed to the development of approximately 40 drugs including acyclovir for herpes and atorvastatin for cholesterol management.
Working on that timescale has long stymied biologists, but the rapid evolution of time-resolved cryo-electron microscopy (TR cryo-EM) over the past several years has made it possible to reconstruct dynamic processes with near-atomic detail.
Evans' discovery of nuclear hormone receptors has transformed drug development, impacting treatments for diseases like diabetes and cancer, and underscoring the influence of biochemistry in medicine.
"Therapies aimed at improving mitochondrial activity could benefit inflammatory diseases such as inflammatory bowel disease, sepsis, and chronic infections by enhancing the immune system's ability to regulate inflammation."