Two of their fourth-round draft picks, running back Isaac Guerendo and receiver Jacob Cowing, ran their 40-yard dashes in under 4.4 seconds, while their top pick, receiver Ricky Pearsall, had a 4.41-second 40.
Safety Malik Mustapha, one of the fourth-round selections, had 80 tackles for Wake Forest and was known for explosive strikes.
The 49ers' draft strategy left them without fifth-round picks, a departure from their historical success in that round, highlighted by George Kittle.
Isaac Guerendo's combination of size and speed was highly sought after by teams like the Miami Dolphins and Houston Texans, given his fit with the 49ers' offense.