Charlie McAvoy's early hit set the tone for the Bruins, but the Panthers rallied for three unanswered goals to secure the win.
Boston challenged a goal by Florida due to a cross-check, but the league determined it didn't affect the outcome.
David Pastrnak expressed frustration over a goal by Sam Bennett, mentioning a previous cheap shot by Bennett on Brad Marchand.
The Bruins, down 3-1 in the series, aim to reverse last season's fate of being eliminated by the Panthers after leading in games.
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