Garrett Crochet struck out 11 in six shutout innings as the White Sox beat the Guardians, improving to 8-6 post a 3-22 start.
Korey Lee and Paul DeJong's back-to-back homers, along with Andrew Vaughn's first season homer, contributed to the White Sox's win.
José Ramírez and Tyler Freeman homered for the Guardians, but they struggled with runners in scoring position, leaving key opportunities vacant.
Cleveland's Carlos Carrasco allowed three earned runs in seven innings, while Chicago capitalized on an error to secure the win in the fifth.
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