Metformin-associated lactic acidosis (MALA) is an uncommon but potentially life-threatening complication linked to the diabetes medication metformin. The condition occurs when excessive lactic acid builds up in the body, leading to dangerous changes in blood chemistry. Researchers developed and evaluated a clinical protocol aimed at improving how MALA is recognized and treated. Their findings were presented at ASN Kidney Week 2025.
You must apply for an approbation (medical license) or a temporary permit - a foreign degree alone is not sufficient. Your medical education must be equivalent in scope and content to a German medical degree. German language proficiency is required: at least B2 (general) and C1 (medical).
As detailed in a new paper published in the journal Nature Communications, the protein-based gel uses the human body's natural growth processes from early in life to form a durable coating and fill in small cavities in teeth. After being coated on a target tooth's surface, it extracts calcium and phosphate ions from saliva to encourage new growth of minerals. These minerals then merge with the existing tooth, effectively allowing it to regrow lost enamel.
Dr. Kevin Sprouse, owner of Podium Sports Medicine andmedical advisor for longevity clinic Eternal, has worked with elite athletes for more than a decade, helping them to achieve peak performance. He told Business Insider that the same science can help anyone live a longer, healthier life - by targeting factors like VO2 max and lactate threshold, key measures of fitness and endurance. His prescription for the best results - even on a tight schedule - is a mix of strength training, steady cardio, and interval training.
In a step toward the wider use of gene editing, a treatment that uses Crispr successfully slashed high cholesterol levels in a small number of people. In a trial conducted by Swiss biotech company Crispr Therapeutics, 15 participants received a one-time infusion meant to switch off a gene in the liver called ANGPTL3. Though rare, some people are born with a mutation in this gene that protects against heart disease with no apparent adverse consequences.
The first near-death experience (NDE) took place in the mid-1980s when Prum went into early labor while pregnant with her oldest son. She suffered dangerously high blood pressure, low blood cell counts, liver problems, and endured seizures. Prum revealed that she left her body during the emergency and entered a state without pain or emotion, looking down from the hospital ceiling as doctors worked to save Prum and her baby.
The recent death of Mary "May" McGee, the brave woman who took the landmark 1973 case on access to contraception in Ireland, was in the forefront of my mind for several days. Any woman who is popping her daily contraceptive pill or buying condoms without a second thought owes her a great debt. Men who have undergone vasectomies may not necessarily know to whom they owe their great debt, as such.
It was a cold November morning, and I had travelled with my family to our ancestral temple in a village in Tamil Nadu. My sister's 11-month-old baby was to be tonsured for the first time a religious head-shaving that in Hinduism is a way of discarding the evil eye and removing any negativity from past lives; a new start. My wife drove, but asked me to park the car while she went inside with our son and her parents.
Three-week-old Theo is fast asleep in a cot, unaware he is helping to trial new technology that could change the lives of others. Dr Flora Faure is gently fitting him with a small black cap that looks like a swimming cap, or something a rugby forward might wear. It is covered with hexagonal lumps, containing technology that monitors how his brain is working.
A doctor accused of pouring beer down a younger colleague's cleavage before licking it off and touching her breasts has been suspended for a year. Dr Mark Johnson, who was working at West Suffolk Hospital at the time of the incident, also allegedly sent "derogatory and sexually demeaning" messages to another junior colleague. Some of these messages included comments about the size of his colleague's breasts, sex positions and oral sex, a tribunal was told.
And not just the ordinary sort of headaches that we all get, but I have something called cluster headache, which is one of the three primary headache disordersI mean, there are other primary headache disorders, but these are the three main ones: tension-type headache being the most common, migraine being probably the most familiar and most debilitatingand predominantly among women.
The OASIS 4 phase 3 trial, published in The New England Journal of Medicine, marks a major advance in Novo Nordisk's effort to expand obesity treatment options. Conducted over 64 weeks, the study compared once-daily oral semaglutide 25 mg plus lifestyle changes with a placebo in 307 adults who were obese or overweight and had at least one weight-related condition, but did not have diabetes.
"Most hospitals don't see enough kids to reliably measure their performance with kids. When most kids go to a community hospital and can't be discharged, they get transferred to a larger hospital. So in those cases, there's no single hospital that owns the outcome," Michelson said. "We think that regions really need to work together to improve pediatric patient outcomes."
Yet most athletes still overlook the one system that can quietly drain speed, stamina, and sleep recovery: the oral system. Over the last 15 years, studies have linked oral problems to endurance outcomes through multiple pathways: low-grade inflammation that blunts recovery and has been associated with small drops in VO2max, pain that derails fueling, bruxism that shreds deep sleep and overnight HRV, and bite mechanics that ripple into posture and load distribution.
A Riverside County woman who for years administered risky and potentially dangerous silicone butt injections was sentenced Wednesday to 15 years to life after an actor died following the procedure, prosecutors said. Libby Adame was convicted in October of second-degree murder in the death of Cindyana Santangelo, whose credited television appearances included "Married ... With Children," "ER" and "CSI: Miami." Adame was also convicted of practicing medicine without a certification after prosecutors said she injected silicone into Santangelo's buttocks, resulting in a fatal embolism.
As a participant in multiple affiliate marketing programs, Localish will earn a commission for certain purchases. See full disclaimer below* As the winter months approach and the air turns drier, using a facial moisturizer can help keep your skin healthy and well-hydrated. But with so many brands and options out there, it's not always simple to pick the right moisturizer for your skin type, especially without some expert guidance.
What is Turner syndrome? Dr. Henry Turner first discovered Turner syndrome in 1938 (Turner Syndrome Foundation, 2024). This condition occurs only in females and is identified by a chromosomal constitution of 45, XO. Typical females have two X chromosomes as indicated by a chromosomal constitution of 46, XX. In the case of Turner syndrome, it seems that one X chromosome is lost very early in the reproductive process.
The family of a woman who died from cervical cancer has settled a High Court action over her death after a hospital acknowledged that there was a missed opportunity to diagnose her illness earlier, which ultimately led to her death.
In this episode of Canadian Time Machine, we mark 150 years since Jennie Trout became the first woman licensed to practice medicine in Canada-a breakthrough that helped open the doors of the profession to women across the country. We hear from historian Heather Stanley about Trout's fight for education and equality, and from Dr. Ramneek Dosanjh, a physician and advocate for equity in healthcare, on the legacy of her achievement.
Somatically acquired mutations in the E1 ubiquitin-activating enzyme UBA1 within hematopoietic stem and progenitor cells (HSPCs) were recently identified as the cause of the adult-onset autoinflammatory syndrome VEXAS (vacuoles, E1 enzyme, X linked, autoinflammatory, somatic)1. UBA1 mutations in VEXAS lead to clonal expansion within the HSPC and myeloid, but not lymphoid, compartments. Despite its severity and prevalence, the mechanisms whereby UBA1 mutations cause multiorgan autoinflammation and hematologic disease are unknown.
I had a lady referred for a potential miscarriage from a clinic and when I scanned her they'd measured a bleed in the womb and they completely missed a very early pregnancy sac with a baby inside it, said Katie Thompson, a hospital sonographer and president of the SoR. Potentially, if they were at a private clinic that could offer a miscarriage service, then they could have been given some medication to bring on a miscarriage on a pregnancy that was actually not miscarrying, she said.
The GLP-1 drug market has surged dramatically in the past four years, driven by soaring demand for weight-loss treatments that also tackle related conditions like diabetes and heart disease. Valued at over $100 billion today, the sector is projected to exceed $150 billion by 2030 as more patients seek effective therapies. Viking Therapeutics ( NASDAQ:VKTX ) is carving out a strong position with its dual GLP-1/GIP agonist VK2735, which showed up to 15% weight loss in Phase 2 trials.
She's happy, healthy, and everything we could've hoped for. I had a vaginal birth at 36 weeks with just a bit of tearing, nothing too major, thankfully, and recovery has been going pretty well so far," she prefaces in her post on the Mommit subreddit. She notes that she's missing "intimacy" with her husband, noting the last time they had sex was when she was 32 weeks pregnant.
Dr. Aaron Hartman will never forget the first time he saw Anna. She was 12 months old, sitting in a Bumbo chair on a Winnie the Pooh blanket, her tiny body unable to support itself. An eye patch covered her "strong" eye-not because it was injured, but because her brain had suffered such severe birth trauma that it affected her eye function. Her hands were curled tightly to her chest, classic signs of the brain damage she'd endured before birth.