#chromatin-accessibility

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#tdac-seq #noncoding-dna #gene-regulation #major-depression #excitatory-neurons #microglia
Medicine
fromHarvard Gazette
1 day ago

Shining a light on the dark matter of our genome - Harvard Gazette

TDAC-seq maps single-nucleotide effects on chromatin, revealing how noncoding DNA variants reshape gene regulation and enabling targeted genetic-disease strategies.
Mental health
fromPsychology Today
1 month ago

Rethinking Depression: Beyond Chemical Imbalance

Major depression involves altered chromatin accessibility in specific brain cell types, indicating gene-regulation rewiring rather than only a simple chemical imbalance.
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