MIT researchers have mapped cellular responses to high-fat diets, revealing enzyme dysregulation connected to weight gain and increased disease risk. Their study on mice demonstrated that a high-fat diet disrupts hundreds of enzymes related to sugar, lipid, and protein metabolism, leading to insulin resistance and toxic molecule buildup, predominantly in males. Interestingly, administering antioxidants alongside a high-fat diet showed promise in reversing these harmful changes, highlighting potential therapeutic avenues for diet-induced metabolic disorders.
"Under metabolic stress conditions, enzymes can be affected to produce a more harmful state than what was initially there... you can bring them to a different state that is less dysfunctional."
"These disruptions lead to an increase in insulin resistance and an accumulation of damaging molecules called reactive oxygen species... effects were more pronounced in males than females."
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